4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&

Name: 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&
Brand: Zhengzhou Whchem

CAS：89238-99-3 | 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& | Whchem

CAS: 89238-99-3

Other Names

4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&;2,2,2-Trichloroacetimidic Acid 4-Methoxybenzyl Ester;4-Methoxybenzyl 2,2,2-Trichloroacetimidate;4-Methoxybenzyl trichloroacetimidate;4-methoxybenzyl 2,2,2-trichloroethanimidoate;4-Methoxybenzyl trichloroacetamidate;4-Methoxybenzyl2,2,2-Trichloroacetimidate>2,2,2-trichlorohydrin-4-methoxybenzyl ester per acetic acid

Structure - 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&

Molecular Formula

Purity

>98%

Molecular Weight

282.55 g/mol

EINECS

Structure Available Verified Product

English Name	4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&
English Synonyms	4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&;2,2,2-Trichloroacetimidic Acid 4-Methoxybenzyl Ester;4-Methoxybenzyl 2,2,2-Trichloroacetimidate;4-Methoxybenzyl trichloroacetimidate;4-methoxybenzyl 2,2,2-trichloroethanimidoate;4-Methoxybenzyl trichloroacetamidate;4-Methoxybenzyl2,2,2-Trichloroacetimidate>2,2,2-trichlorohydrin-4-methoxybenzyl ester per acetic acid
CAS Number	89238-99-3
Molecular Formula	C10H10Cl3NO2
Molecular Weight	282.55 g/mol
EINECS Number
Related Categories	Others;Protecting and Derivatizing Reagents;Protection and Derivatization;Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry
Mol File	Download MOL File
Structure Image

Property	Value
Boiling point	137 °C / 0.7 mmHg
Density	1.361 g/mL at 25 °C
Refractive index	n20/D 1.5488
Flash point	110 °C
Storage condition	2-8°C
Acidity Coefficient (pKa)	1.96±0.70 (Predicted)
Form	Clear liquid
Color	Colorless to pale yellow to light orange
Major application	Peptide synthesis
InChI	InChI=1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
InChIKey	TYHGKLBJBHACOI-UHFFFAOYSA-N
SMILES	C(=N)(OCC1=CC=C(OC)C=C1)C(Cl)(Cl)Cl

4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& (CAS 89238-99-3) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods 4-Methoxybenzyl 2,2,2-Trichloroacetimidate	Uses & Synthesis Methods Uses: 4-Methoxybenzyl 2,2,2-trichloroacetimidate is a commonly used reagent in organic synthesis, particularly in peptide synthesis. It serves as an efficient reagent for the protection of hydroxyl and amino groups. The 4-methoxybenzyl (PMB) group is a widely used protecting group for alcohols and amines, and the trichloroacetimidate functionality allows for mild and selective introduction of the PMB group under acidic conditions. It is also used in glycosylation reactions and as an intermediate in the synthesis of various bioactive molecules and natural products. Synthesis Methods: The compound can be synthesized by the reaction of 4-methoxybenzyl alcohol with trichloroacetonitrile in the presence of a base such as sodium hydride or DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). A typical procedure involves dissolving 4-methoxybenzyl alcohol in a solvent such as dichloromethane or THF, adding the base, and then slowly adding trichloroacetonitrile at low temperature (0°C to room temperature). The reaction mixture is stirred until completion, and the product is isolated by removal of the solvent and purified by column chromatography or distillation to afford the desired imidate as a colorless to pale yellow liquid.

Category

Description (English Translation)

Uses & Synthesis Methods

4-Methoxybenzyl 2,2,2-Trichloroacetimidate

Uses & Synthesis Methods

Uses: 4-Methoxybenzyl 2,2,2-trichloroacetimidate is a commonly used reagent in organic synthesis, particularly in peptide synthesis. It serves as an efficient reagent for the protection of hydroxyl and amino groups. The 4-methoxybenzyl (PMB) group is a widely used protecting group for alcohols and amines, and the trichloroacetimidate functionality allows for mild and selective introduction of the PMB group under acidic conditions. It is also used in glycosylation reactions and as an intermediate in the synthesis of various bioactive molecules and natural products.

Synthesis Methods: The compound can be synthesized by the reaction of 4-methoxybenzyl alcohol with trichloroacetonitrile in the presence of a base such as sodium hydride or DBU (1,8-diazabicyclo[5.4.0]undec-7-ene). A typical procedure involves dissolving 4-methoxybenzyl alcohol in a solvent such as dichloromethane or THF, adding the base, and then slowly adding trichloroacetonitrile at low temperature (0°C to room temperature). The reaction mixture is stirred until completion, and the product is isolated by removal of the solvent and purified by column chromatography or distillation to afford the desired imidate as a colorless to pale yellow liquid.

Category	Value
Hazard Symbol	Xn, N
Hazard Codes (R Phrases)	20/21/22-36/37/38-51/53
Safety Codes (S Phrases)	26-61-36/37
UN Number	UN 3082 9/PG 3
WGK Germany	3
HS Code (Customs)	29252900
Storage Category	11 - Combustible solids

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4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID&

CAS：89238-99-3 | 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID& | Whchem

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