Monomethyl succinate

Name: Monomethyl succinate
Brand: Zhengzhou Whchem

CAS：77341-67-4 | Monomethyl succinate | Whchem

CAS: 77341-67-4

Other Names

MONO-MENTHYLSUCCINATE;4-(((1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl)oxy)-4-oxobutanoic acid;Butanedioic acid mono-(5-methyl-2-isopropyl-cyclohexyl) ester;Monomethyl succinate;Mononmethyl succinate;4-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-4-oxobutanoic acid;(-)-MenthylSuccinate>Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester

Molecular Formula

Purity

>97%

Molecular Weight

256.34 g/mol

EINECS

Structure Available Verified Product

English Name	Monomethyl succinate
English Synonyms	MONO-MENTHYLSUCCINATE;4-(((1R,2S,5R)-2-Isopropyl-5-Methylcyclohexyl)oxy)-4-oxobutanoic acid;Butanedioic acid mono-(5-methyl-2-isopropyl-cyclohexyl) ester;Monomethyl succinate;Mononmethyl succinate;4-[(1R,2S,5R)-5-methyl-2-propan-2-ylcyclohexyl]oxy-4-oxobutanoic acid;(-)-MenthylSuccinate>Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester
CAS Number	77341-67-4
Molecular Formula	C14H24O4
Molecular Weight	256.34 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	62.0 to 66.0 °C
Boiling point	374.3±25.0 °C (Predicted)
Density	1.06±0.1 g/cm³ (Predicted)
FEMA	3810 \| MONO-MENTHYL SUCCINATE
Storage condition	Sealed in dry, Room Temperature
Solubility	Soluble in methanol
Acidity Coefficient (pKa)	4.42±0.17 (Predicted)
Form	Powder crystals
Color	White to off-white
Odor	Odorless
Flavor Type	Odorless
JECFA Number	447
Cosmetic Ingredient Function	ASTRINGENT
LogP	4.35
EPA Chemical Substance Reference	Butanedioic acid, 1-[(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl] ester (77341-67-4)

Monomethyl succinate (CAS 77341-67-4) is available through Zhengzhou Whchem custom synthesis services, from gram-scale R&D to ton-scale commercial production.

Our team delivers Monomethyl succinate with >97% purity, custom packaging and full analytical support per project requirements.

Category	Description (English Translation)
Uses & Synthesis Methods	Toxicity: GRAS (FEMA). Use Limits (FEMA mg/kg): Baked goods 300–900; Cold drinks 70–120; Soft candy 200–600; Gelatin products, puddings 150–450; Beverages 40–120; Dairy products 60–180; Fruit ice products 70–120; Confections, frostings, hard candy 200–600; Jams, jellies 150–450; Chewing gum 1250–3750. Uses: Food additive. Production Methods: Starting Materials: 108-30-5 (Succinic anhydride) 2216-51-5 (L-Menthol) 77341-67-4 (Mono-menthyl succinate) Synthesis Example 1: Synthesis of 1-Menthyl-(1-menthoxyethyl)succinate Synthesis of Compound 1: To a 100 mL autoclave, 10.00 g (63.99 mmol) of L-menthol and 6.40 g (63.96 mmol) of succinic anhydride were added. The air inside the autoclave was replaced with nitrogen. Subsequently, the mixture was stirred at 110°C for 8 hours. After the reaction was complete, the mixture was cooled to room temperature, and 100 mL of hexane was added. The precipitated crystals were filtered off, and the hexane phase in the filtrate was concentrated to give 16.61 g of 1-menthyl succinate with purity > 99.9%. References: [1] Patent: US2011/81393, 2011, A1. Location in patent: Page/Page column 10 [2] Molecules, 2005, vol. 10, # 1, p. 81 - 97 [3] Molecular Crystals and Liquid Crystals, 2015, vol. 609, # 1, p. 31 - 39 [4] Patent: US2009/28803, 2009, A1

Category

Description (English Translation)

Uses & Synthesis Methods

Toxicity: GRAS (FEMA).

Use Limits (FEMA mg/kg): Baked goods 300–900; Cold drinks 70–120; Soft candy 200–600; Gelatin products, puddings 150–450; Beverages 40–120; Dairy products 60–180; Fruit ice products 70–120; Confections, frostings, hard candy 200–600; Jams, jellies 150–450; Chewing gum 1250–3750.

Uses: Food additive.

Production Methods:

Starting Materials:

108-30-5 (Succinic anhydride)

2216-51-5 (L-Menthol)

77341-67-4 (Mono-menthyl succinate)

Synthesis Example 1: Synthesis of 1-Menthyl-(1-menthoxyethyl)succinate

Synthesis of Compound 1: To a 100 mL autoclave, 10.00 g (63.99 mmol) of L-menthol and 6.40 g (63.96 mmol) of succinic anhydride were added. The air inside the autoclave was replaced with nitrogen. Subsequently, the mixture was stirred at 110°C for 8 hours. After the reaction was complete, the mixture was cooled to room temperature, and 100 mL of hexane was added. The precipitated crystals were filtered off, and the hexane phase in the filtrate was concentrated to give 16.61 g of 1-menthyl succinate with purity > 99.9%.

References:

[1] Patent: US2011/81393, 2011, A1. Location in patent: Page/Page column 10

[2] Molecules, 2005, vol. 10, # 1, p. 81 - 97

[3] Molecular Crystals and Liquid Crystals, 2015, vol. 609, # 1, p. 31 - 39

[4] Patent: US2009/28803, 2009, A1

Category	Value
TSCA	TSCA listed
HS Code (Customs)	2917.19.7050

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Monomethyl succinate

CAS：77341-67-4 | Monomethyl succinate | Whchem

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