PENTAFLUOROPHENYL TRIFLUOROACETATE

Name: PENTAFLUOROPHENYL TRIFLUOROACETATE
Brand: Zhengzhou Whchem

CAS：14533-84-7 | PENTAFLUOROPHENYL TRIFLUOROACETATE | Whchem

CAS: 14533-84-7

Other Names

PFP-O-TFA;PENTAFLUOROPHENYL TRIFLUOROACETATE;PENTAFLUORPHENYL TRIFLUORACETATE;TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER;TFA-OPFP;Pentafluoropfenyl Trifluoroacetate;Pentafluorophenyl trifluoroacetate,Trifluoroacetic acid pentafluorophenyl ester;Pentafluorophenyl trifluoroacetate, 98+%

Structure - PENTAFLUOROPHENYL TRIFLUOROACETATE

Molecular Formula

Purity

>99%

Molecular Weight

280.07 g/mol

EINECS

629-320-4

Structure Available Verified Product

English Name	PENTAFLUOROPHENYL TRIFLUOROACETATE
English Synonyms	PFP-O-TFA;PENTAFLUOROPHENYL TRIFLUOROACETATE;PENTAFLUORPHENYL TRIFLUORACETATE;TRIFLUORO ACETIC ACID PENTAFLUORO PHENYL ESTER;TFA-OPFP;Pentafluoropfenyl Trifluoroacetate;Pentafluorophenyl trifluoroacetate,Trifluoroacetic acid pentafluorophenyl ester;Pentafluorophenyl trifluoroacetate, 98+%
CAS Number	14533-84-7
Molecular Formula	C8F8O2
Molecular Weight	280.07 g/mol
EINECS Number	629-320-4
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	4°C (lit.)
Boiling point	122-123 °C (lit.)
Density	1.63 g/mL at 25 °C (lit.)
Refractive index	n20/D 1.368 (lit.)
Flash point	126 °F
Storage condition	Keep in dark place, Sealed in dry, 2-8°C
Form	Oily
Color	Transparent colorless
Specific gravity	1.630
Water solubility	Soluble in water at 122.5°C at 760 mmHg.
Sensitivity	Moisture Sensitive
BRN	2003848
Major application	peptide synthesis
InChI	InChI=1S/C8F8O2/c9-1-2(10)4(12)6(5(13)3(1)11)18-7(17)8(14,15)16
InChIKey	VCQURUZYYSOUHP-UHFFFAOYSA-N
SMILES	C(OC1=C(F)C(F)=C(F)C(F)=C1F)(=O)C(F)(F)F
CAS Database Reference	14533-84-7 (CAS DataBase Reference)

PENTAFLUOROPHENYL TRIFLUOROACETATE (CAS 14533-84-7) is a pharmaceutical intermediate widely used in drug discovery, API synthesis and commercial pharmaceutical manufacturing.

Zhengzhou Whchem supplies PENTAFLUOROPHENYL TRIFLUOROACETATE with >99% purity, complete analytical documentation and reliable global logistics for R&D and production needs.

Category	Description (English Translation)
Application	Pentafluorophenyl trifluoroacetate can be used as an organic synthesis intermediate and as a raw material for the synthesis of fluorine-containing drug molecules. It has certain applications in the fluorochemical industry.
Preparation Method	In a dry reaction flask, trifluoroacetic anhydride (4.9 mL, typically 2.5-4 equivalents) is added to a solution of pentafluorophenol in toluene. The resulting reaction mixture is stirred under an argon atmosphere at reflux for approximately 1-2 hours to form a homogeneous reaction mixture. After the reaction is complete, the reaction mixture is directly concentrated under reduced pressure (rotary evaporation) to remove excess reagents and the by-product CF₃COOH. The obtained solid product is dried under high vacuum for 3-4 hours to give pentafluorophenyl trifluoroacetate, which is stored under argon (Ar) or nitrogen (N₂).

Category

Description (English Translation)

Application

Pentafluorophenyl trifluoroacetate can be used as an organic synthesis intermediate and as a raw material for the synthesis of fluorine-containing drug molecules. It has certain applications in the fluorochemical industry.

Preparation Method

In a dry reaction flask, trifluoroacetic anhydride (4.9 mL, typically 2.5-4 equivalents) is added to a solution of pentafluorophenol in toluene. The resulting reaction mixture is stirred under an argon atmosphere at reflux for approximately 1-2 hours to form a homogeneous reaction mixture. After the reaction is complete, the reaction mixture is directly concentrated under reduced pressure (rotary evaporation) to remove excess reagents and the by-product CF₃COOH. The obtained solid product is dried under high vacuum for 3-4 hours to give pentafluorophenyl trifluoroacetate, which is stored under argon (Ar) or nitrogen (N₂).

Category	Value
Hazard Symbols	Xi, F
Hazard Codes	10-36/37/38
Safety Codes	16-26-36
UN Number	UN 3272 3/PG 3
WGK Germany	3
Hazard Class	3.2
Packing Group	III
HS Code	29159000
Storage Category	3 - Flammable liquids
Hazard Classification	Eye Irritation Category 2, Flammable Liquid Category 3, Dermal Irritation Category 2, Specific Target Organ Toxicity - Single Exposure Category 3

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PENTAFLUOROPHENYL TRIFLUOROACETATE

CAS：14533-84-7 | PENTAFLUOROPHENYL TRIFLUOROACETATE | Whchem

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