TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE

Name: TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE
Brand: Zhengzhou Whchem

CAS：121898-64-4 | TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE | Whchem

CAS: 121898-64-4

Other Names

TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE;TRIS(3,5-DIMETHYL-4-METHOXY)PHOSPHINE;TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE,MIN.98%;tris(4-methoxy-3,5-dimethylphenyl)phosphine,min.;Tris(4-methoxy-3,5-dimethylphenyl)phosphine, 98+%;Tris(4-methoxy-3,5-dimethylphenyl)phosphine 97%;Tris(4-methoxy-3,5-dimethylphenyl);TRIS(4-METOXY-3,5-DIMETHYLPHENYL)PHOSPHIN

Structure - TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE

Molecular Formula

Purity

>98%

Molecular Weight

436.52 g/mol

EINECS

Structure Available Verified Product

English Name	TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE
English Synonyms	TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE;TRIS(3,5-DIMETHYL-4-METHOXY)PHOSPHINE;TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE,MIN.98%;tris(4-methoxy-3,5-dimethylphenyl)phosphine,min.;Tris(4-methoxy-3,5-dimethylphenyl)phosphine, 98+%;Tris(4-methoxy-3,5-dimethylphenyl)phosphine 97%;Tris(4-methoxy-3,5-dimethylphenyl);TRIS(4-METOXY-3,5-DIMETHYLPHENYL)PHOSPHIN
CAS Number	121898-64-4
Molecular Formula	C27H33O3P
Molecular Weight	436.52 g/mol
EINECS Number
Related Categories	Achiral Phosphine;Aryl Phosphine;organophosphine compound
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	174-179 °C
Boiling point	539.3±50.0 °C (Predicted)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Form	Crystals
Color	White
InChI	InChI=1S/C27H33O3P/c1-16-10-22(11-17(2)25(16)28-7)31(23-12-18(3)26(29-8)19(4)13-23)24-14-20(5)27(30-9)21(6)15-24/h10-15H,1-9H3
InChIKey	BDGUINGZRGNLPD-UHFFFAOYSA-N
SMILES	COc1c(C)cc(cc1C)P(c2cc(C)c(OC)c(C)c2)c3cc(C)c(OC)c(C)c3

TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE (CAS 121898-64-4) is an organophosphorus compound and phosphine-based material used in cross-coupling catalysis, ligand synthesis, flame retardants and electronic chemicals.

Zhengzhou Whchem supplies TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE with >98% purity, supporting both laboratory research and industrial production.

Category	Description (English Translation)
Uses & Synthesis Methods Tris(4-methoxy-3,5-dimethylphenyl)phosphine	Uses & Synthesis Methods Uses: Tris(4-methoxy-3,5-dimethylphenyl)phosphine is a triarylphosphine ligand with electron-donating methoxy and methyl substituents. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions. The electron-rich phosphine enhances oxidative addition and stabilizes metal centers, improving catalytic efficiency. It also serves as a reagent in organic synthesis and as a precursor for other phosphine derivatives. Synthesis Methods: This compound can be synthesized via a lithium-halogen exchange reaction. A typical method involves the reaction of 5-bromo-2-methoxy-1,3-dimethylbenzene with n-butyllithium to generate the corresponding aryllithium intermediate, which is then reacted with phosphorus trichloride (PCl₃) to form the desired triarylphosphine. The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran (THF) at low temperatures. The product is purified by recrystallization or column chromatography. Due to its air sensitivity, it should be stored under an inert atmosphere (nitrogen or argon) at 2-8°C.

Category

Description (English Translation)

Uses & Synthesis Methods

Tris(4-methoxy-3,5-dimethylphenyl)phosphine

Uses & Synthesis Methods

Uses: Tris(4-methoxy-3,5-dimethylphenyl)phosphine is a triarylphosphine ligand with electron-donating methoxy and methyl substituents. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions. The electron-rich phosphine enhances oxidative addition and stabilizes metal centers, improving catalytic efficiency. It also serves as a reagent in organic synthesis and as a precursor for other phosphine derivatives.

Synthesis Methods: This compound can be synthesized via a lithium-halogen exchange reaction. A typical method involves the reaction of 5-bromo-2-methoxy-1,3-dimethylbenzene with n-butyllithium to generate the corresponding aryllithium intermediate, which is then reacted with phosphorus trichloride (PCl₃) to form the desired triarylphosphine. The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran (THF) at low temperatures. The product is purified by recrystallization or column chromatography. Due to its air sensitivity, it should be stored under an inert atmosphere (nitrogen or argon) at 2-8°C.

Category	Value
Hazard Symbol	Xi
Hazard Codes (R Phrases)	36/37/38
Safety Codes (S Phrases)	26-36/37/39
WGK Germany	3
TSCA	No
Storage Category	11 - Combustible solids
Hazard Classification	Hazardous to the Aquatic Environment - Long-term Hazard Category 4, Eye Irritation Category 2, Dermal Irritation Category 2, Specific Target Organ Toxicity - Single Exposure Category 3

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TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE

CAS：121898-64-4 | TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE | Whchem

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TRIS(4-METHOXY-3,5-DIMETHYLPHENYL)PHOSPHINE

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