tris(3,5-di-tert-butylphenyl)phosphine

Name: tris(3,5-di-tert-butylphenyl)phosphine
Brand: Zhengzhou Whchem

CAS：189756-42-1 | tris(3,5-di-tert-butylphenyl)phosphine | Whchem

CAS: 189756-42-1

Other Names

tris(3,5-di-tert-butylphenyl)phosphine;Phosphine, tris[3,5-bis(1,1-dimethylethyl)phenyl]-;ris(3,5-di-tert-butylphenyl)phosphine;Tris(3,5-di-tert-butylphenyl)phosphane;Tri (3,5-di-tert-butylphenyl) phosphine

Structure - tris(3,5-di-tert-butylphenyl)phosphine

Molecular Formula

Purity

>98%

Molecular Weight

598.92 g/mol

EINECS

Structure Available Verified Product

English Name	tris(3,5-di-tert-butylphenyl)phosphine
English Synonyms	tris(3,5-di-tert-butylphenyl)phosphine;Phosphine, tris[3,5-bis(1,1-dimethylethyl)phenyl]-;ris(3,5-di-tert-butylphenyl)phosphine;Tris(3,5-di-tert-butylphenyl)phosphane;Tri (3,5-di-tert-butylphenyl) phosphine
CAS Number	189756-42-1
Molecular Formula	C42H63P
Molecular Weight	598.92 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Boiling point	586.5±50.0 °C (Predicted)
Storage condition	2-8°C, stored under nitrogen
Appearance	White to off-white solid

tris(3,5-di-tert-butylphenyl)phosphine (CAS 189756-42-1) is an organophosphorus compound and phosphine-based material used in cross-coupling catalysis, ligand synthesis, flame retardants and electronic chemicals.

Zhengzhou Whchem supplies tris(3,5-di-tert-butylphenyl)phosphine with >98% purity, supporting both laboratory research and industrial production.

Category	Description (English Translation)
Uses & Synthesis Methods Tris(3,5-di-tert-butylphenyl)phosphine	Uses & Synthesis Methods Uses: Tris(3,5-di-tert-butylphenyl)phosphine is a sterically hindered phosphine ligand. Due to the presence of bulky tert-butyl groups, it exhibits unique steric and electronic properties. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions (such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions), where it can stabilize low-valent metal centers and improve reaction selectivity. It is also used in organometallic chemistry and as a reagent in various organic transformations. Synthesis Methods: This compound can be synthesized via a lithium-halogen exchange reaction. A typical method involves the reaction of 1-bromo-3,5-di-tert-butylbenzene with n-butyllithium to generate the corresponding aryllithium intermediate, which is then reacted with phosphorus trichloride (PCl₃) to form the desired triarylphosphine. The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran (THF) at low temperatures, and the product is purified by recrystallization or column chromatography. Due to its air sensitivity, it should be stored under nitrogen at 2-8°C.

Category

Description (English Translation)

Uses & Synthesis Methods

Tris(3,5-di-tert-butylphenyl)phosphine

Uses & Synthesis Methods

Uses: Tris(3,5-di-tert-butylphenyl)phosphine is a sterically hindered phosphine ligand. Due to the presence of bulky tert-butyl groups, it exhibits unique steric and electronic properties. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions (such as Suzuki-Miyaura, Heck, and Buchwald-Hartwig reactions), where it can stabilize low-valent metal centers and improve reaction selectivity. It is also used in organometallic chemistry and as a reagent in various organic transformations.

Synthesis Methods: This compound can be synthesized via a lithium-halogen exchange reaction. A typical method involves the reaction of 1-bromo-3,5-di-tert-butylbenzene with n-butyllithium to generate the corresponding aryllithium intermediate, which is then reacted with phosphorus trichloride (PCl₃) to form the desired triarylphosphine. The reaction is usually carried out in an inert solvent such as diethyl ether or tetrahydrofuran (THF) at low temperatures, and the product is purified by recrystallization or column chromatography. Due to its air sensitivity, it should be stored under nitrogen at 2-8°C.

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tris(3,5-di-tert-butylphenyl)phosphine

CAS：189756-42-1 | tris(3,5-di-tert-butylphenyl)phosphine | Whchem

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tris(3,5-di-tert-butylphenyl)phosphine

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