Phosphine, (4-ethynylphenyl)diphenyl-

Name: Phosphine, (4-ethynylphenyl)diphenyl-
Brand: Zhengzhou Whchem

CAS：359017-78-0 | Phosphine, (4-ethynylphenyl)diphenyl- | Whchem

CAS: 359017-78-0

Other Names

Phosphine, (4-ethynylphenyl)diphenyl-;1-(diphenylphosphanyl)-4-ethynylbenzene;(4-ethynylphenyl)diphenylphosphine

Structure - Phosphine, (4-ethynylphenyl)diphenyl-

Molecular Formula

Purity

>98%

Molecular Weight

286.31 g/mol

EINECS

Structure Available Verified Product

English Name	Phosphine, (4-ethynylphenyl)diphenyl-
English Synonyms	Phosphine, (4-ethynylphenyl)diphenyl-;1-(diphenylphosphanyl)-4-ethynylbenzene;(4-ethynylphenyl)diphenylphosphine
CAS Number	359017-78-0
Molecular Formula	C20H15P
Molecular Weight	286.31 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Boiling point	386.4±25.0 °C (Predicted)
Storage condition	2-8°C, stored under nitrogen
Appearance	Pale yellow to brown solid

Phosphine, (4-ethynylphenyl)diphenyl- (CAS 359017-78-0) is an organophosphorus compound and phosphine-based material used in cross-coupling catalysis, ligand synthesis, flame retardants and electronic chemicals.

Zhengzhou Whchem supplies Phosphine, (4-ethynylphenyl)diphenyl- with >98% purity, supporting both laboratory research and industrial production.

Category	Description (English Translation)
Uses & Synthesis Methods (4-Ethynylphenyl)diphenylphosphine	Uses & Synthesis Methods Uses: (4-Ethynylphenyl)diphenylphosphine is a versatile organophosphorus compound containing both a phosphine group and a terminal alkyne. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions such as Sonogashira, Suzuki-Miyaura, and Heck reactions. The terminal alkyne group allows for further functionalization via click chemistry and other alkyne-based transformations. It also serves as a building block in the synthesis of conjugated polymers, fluorescent materials, and bioactive molecules. Synthesis Methods: This compound can be synthesized by the reaction of (4-bromophenyl)diphenylphosphine with trimethylsilylacetylene (TMS-acetylene) under Sonogashira coupling conditions, followed by deprotection of the TMS group. A typical procedure involves using a palladium catalyst (e.g., Pd(PPh₃)₂Cl₂) and copper(I) iodide as a co-catalyst in an amine solvent (e.g., triethylamine or diisopropylamine) under an inert atmosphere. The resulting TMS-protected alkyne is then deprotected using a base such as potassium carbonate or tetrabutylammonium fluoride to yield the desired terminal alkyne. The product is purified by column chromatography and stored under nitrogen at 2-8°C.

Category

Description (English Translation)

Uses & Synthesis Methods

(4-Ethynylphenyl)diphenylphosphine

Uses & Synthesis Methods

Uses: (4-Ethynylphenyl)diphenylphosphine is a versatile organophosphorus compound containing both a phosphine group and a terminal alkyne. It is widely used as a ligand in transition metal catalysis, particularly in palladium-catalyzed cross-coupling reactions such as Sonogashira, Suzuki-Miyaura, and Heck reactions. The terminal alkyne group allows for further functionalization via click chemistry and other alkyne-based transformations. It also serves as a building block in the synthesis of conjugated polymers, fluorescent materials, and bioactive molecules.

Synthesis Methods: This compound can be synthesized by the reaction of (4-bromophenyl)diphenylphosphine with trimethylsilylacetylene (TMS-acetylene) under Sonogashira coupling conditions, followed by deprotection of the TMS group. A typical procedure involves using a palladium catalyst (e.g., Pd(PPh₃)₂Cl₂) and copper(I) iodide as a co-catalyst in an amine solvent (e.g., triethylamine or diisopropylamine) under an inert atmosphere. The resulting TMS-protected alkyne is then deprotected using a base such as potassium carbonate or tetrabutylammonium fluoride to yield the desired terminal alkyne. The product is purified by column chromatography and stored under nitrogen at 2-8°C.

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Phosphine, (4-ethynylphenyl)diphenyl-

CAS：359017-78-0 | Phosphine, (4-ethynylphenyl)diphenyl- | Whchem

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Phosphine, (4-ethynylphenyl)diphenyl-

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