(4-METHOXY-BENZOYLAMINO)-ACETIC ACID

Name: (4-METHOXY-BENZOYLAMINO)-ACETIC ACID
Brand: Zhengzhou Whchem

CAS：13214-64-7 | (4-METHOXY-BENZOYLAMINO)-ACETIC ACID | Whchem

CAS: 13214-64-7

Other Names

(4-METHOXY-BENZOYLAMINO)-ACETIC ACID;4-methyoxybenzoyl-N-glycine;N-(4-Methoxybenzoyl)glycine;p-Methoxyhippuric acid;2-(4-MethoxybenzaMido)acetic acid;2-[(4-METHOXYBENZOYL)AMINO]ACETIC ACID;IFLAB-BB F1130-0072;2-[(4-methoxyphenyl)carbonylamino]ethanoic acid

Structure - (4-METHOXY-BENZOYLAMINO)-ACETIC ACID

Molecular Formula

Purity

>98%

Molecular Weight

209.2 g/mol

EINECS

Structure Available Verified Product

English Name	(4-METHOXY-BENZOYLAMINO)-ACETIC ACID
English Synonyms	(4-METHOXY-BENZOYLAMINO)-ACETIC ACID;4-methyoxybenzoyl-N-glycine;N-(4-Methoxybenzoyl)glycine;p-Methoxyhippuric acid;2-(4-MethoxybenzaMido)acetic acid;2-[(4-METHOXYBENZOYL)AMINO]ACETIC ACID;IFLAB-BB F1130-0072;2-[(4-methoxyphenyl)carbonylamino]ethanoic acid
CAS Number	13214-64-7
Molecular Formula	C10H11NO4
Molecular Weight	209.2 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	155-158°
Boiling point	463.7±30.0 °C (Predicted)
Density	1.268±0.06 g/cm³ (Predicted)
Storage condition	Sealed in dry, Room Temperature
Acidity Coefficient (pKa)	3.53±0.10 (Predicted)
Appearance	White to off-white solid

(4-METHOXY-BENZOYLAMINO)-ACETIC ACID (CAS 13214-64-7) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides (4-METHOXY-BENZOYLAMINO)-ACETIC ACID with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Production Method: Starting Materials: 51220-57-6 13214-64-7 General procedure for the synthesis of 2-(4-methoxybenzamido)acetic acid from compound (CAS: 51220-57-6): When R₁ is methoxyphenyl, synthesis of compound g is performed as follows: 4-Methoxybenzoic acid a (2.00 g, 13.80 mmol) was placed in a 200 mL round-bottom flask, and 60 mL of dichloromethane (DCM) was added. EDCI (13.80 mmol), HOBt (13.80 mmol), compound b (15.77 mmol), and triethylamine (Et₃N, 45.99 mmol) were then added sequentially. The reaction mixture was stirred at room temperature overnight. After completion, the mixture was washed successively with water, saturated ammonium chloride solution, and saturated brine. The organic phase was dried over anhydrous sodium sulfate. Purification by column chromatography (petroleum ether:ethyl acetate = 5:1 to 2:1) afforded compound c (1.80 g, 62.7% yield). Compound c was then added directly to a mixture of 45 mL methanol and 45 mL aqueous sodium hydroxide (15.19 mmol), and heated under reflux for 3 hours. After completion, the mixture was cooled to room temperature and the solvent was evaporated. A small amount of water was added, and the mixture was transferred to a beaker and adjusted to pH 1-2 with concentrated hydrochloric acid. The mixture was extracted with ethyl acetate (EA). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to afford white solid d (1.22 g, 76.5% yield). References: [1] Organic Letters, 2016, vol. 18, # 4, p. 696 - 699 [2] Patent: CN107216282, 2017, A. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064

Category

Description (English Translation)

Uses & Synthesis Methods

Production Method:

Starting Materials:
51220-57-6
13214-64-7

General procedure for the synthesis of 2-(4-methoxybenzamido)acetic acid from compound (CAS: 51220-57-6):

When R₁ is methoxyphenyl, synthesis of compound g is performed as follows: 4-Methoxybenzoic acid a (2.00 g, 13.80 mmol) was placed in a 200 mL round-bottom flask, and 60 mL of dichloromethane (DCM) was added. EDCI (13.80 mmol), HOBt (13.80 mmol), compound b (15.77 mmol), and triethylamine (Et₃N, 45.99 mmol) were then added sequentially. The reaction mixture was stirred at room temperature overnight. After completion, the mixture was washed successively with water, saturated ammonium chloride solution, and saturated brine. The organic phase was dried over anhydrous sodium sulfate. Purification by column chromatography (petroleum ether:ethyl acetate = 5:1 to 2:1) afforded compound c (1.80 g, 62.7% yield).

Compound c was then added directly to a mixture of 45 mL methanol and 45 mL aqueous sodium hydroxide (15.19 mmol), and heated under reflux for 3 hours. After completion, the mixture was cooled to room temperature and the solvent was evaporated. A small amount of water was added, and the mixture was transferred to a beaker and adjusted to pH 1-2 with concentrated hydrochloric acid. The mixture was extracted with ethyl acetate (EA). The organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to afford white solid d (1.22 g, 76.5% yield).

References:
[1] Organic Letters, 2016, vol. 18, # 4, p. 696 - 699
[2] Patent: CN107216282, 2017, A. Location in patent: Paragraph 0060; 0061; 0062; 0063; 0064

Request Quotation or Technical Data

Fill out the form to request pricing, technical data sheets, or samples. Our team will respond within 24 hours.

[email protected]

Phone

8618638188764

Address

Parkin Building, Cuizhu Street, High-tech Development Zone, Zhengzhou, China

WeChat

Scan to connect

Quick response guaranteed

PRODUCT_CATEGORIES

Chemical Intermediates

Pharmaceutical Intermediates

OLED Intermediates

Advanced Organophosphorus Materials

Custom Synthesis

All Products

(4-METHOXY-BENZOYLAMINO)-ACETIC ACID

CAS：13214-64-7 | (4-METHOXY-BENZOYLAMINO)-ACETIC ACID | Whchem

You May Also Be Interested In

2-diethoxyphosphoryl-N,N-dimethylacetamide

4-METHYLESCULETIN

CARBONIC ACID ALLYL ETHYL ESTER

Request Quotation or Technical Data

(4-METHOXY-BENZOYLAMINO)-ACETIC ACID

CAS：13214-64-7 | (4-METHOXY-BENZOYLAMINO)-ACETIC ACID | Whchem

You May Also Be Interested In

2-diethoxyphosphoryl-N,N-dimethylacetamide

4-METHYLESCULETIN

CARBONIC ACID ALLYL ETHYL ESTER

Request Quotation or Technical Data

Product Inquiry