N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Name: N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
Brand: Zhengzhou Whchem

CAS：1477-57-2 | N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) | Whchem

CAS: 1477-57-2

Other Names

FERTILYSIN;N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE;N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE];N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE);bisdiamine;bis-diamine;n,n’,1,8-octanediylbis(2,2-dichloro-acetamid;n,n’-bis(dichloroacetyl)-1,8-diaminooctane

Structure - N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

Molecular Formula

Purity

>97%

Molecular Weight

366.11 g/mol

EINECS

216-033-0

Structure Available Verified Product

English Name	N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)
English Synonyms	FERTILYSIN;N,N'-BIS(DICHLOROACETYL)-1,8-OCTAMETHYLENEDIAMINE;N,N'-OCTA-METHYLENE-BIS[2,2-DICHLOROACETAMIDE];N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE);bisdiamine;bis-diamine;n,n’,1,8-octanediylbis(2,2-dichloro-acetamid;n,n’-bis(dichloroacetyl)-1,8-diaminooctane
CAS Number	1477-57-2
Molecular Formula	C12H20Cl4N2O2
Molecular Weight	366.11 g/mol
EINECS Number	216-033-0
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	118-120 °C
Boiling point	530℃
Density	0.726
Refractive index	1.6200 (estimate)
Flash point	275℃
Storage condition	Inert atmosphere, 2-8°C
Solubility	Soluble in acetone (very slightly), DMSO (slightly), methanol (slightly, with heating and sonication)
Acidity Coefficient (pKa)	12.28±0.46 (Predicted)
Form	Solid
Color	White to off-white
InChI	InChI=1S/C12H20Cl4N2O2/c13-9(14)11(19)17-7-5-3-1-2-4-6-8-18-12(20)10(15)16/h9-10H,1-8H2,(H,17,19)(H,18,20)
InChIKey	FAOMZVDZARKPFJ-UHFFFAOYSA-N
SMILES	O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
CAS Database Reference	1477-57-2

N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) (CAS 1477-57-2) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods N,N'-Octamethylenebis(dichloroacetamide)	Uses & Synthesis Methods Biological Activity: Win 18446 is an orally active, testis-specific inhibitor of the enzyme ALDH1a2 with an IC₅₀ value of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in multiple species and suppresses the synthesis of retinoic acid (HY-14649) from retinol (HY-B1342) in the testes. In Vitro Studies: WIN 18446 (1 μM, 24 h) is able to suppress Stra8 expression in whole-testis cultures that contained both germ and somatic cells.
Parameter	Value
Cell Line	Testes collected from 2-dpp mice
Concentration	1 μM
Incubation Time	24 h
Result	Results in a VAD-like phenotype in the testis. Alone or in combination with ROL significantly reduced Stra8 expression.

In Vivo Studies: Win 18446 (200 mg/kg, orally for 4, 8, and 16 weeks) significantly reduces intratesticular concentrations of retinoic acid, severely impairs spermatogenesis, and causes infertility.

Parameter	Value
Animal Model	Six-month-old male New Zealand white rabbits
Dosage	200 mg/kg
Administration	Oral for 4, 8, and 16 weeks
Result	Resulted in marked suppression of testicular weight over time. Dramatically suppressed spermatogenesis. Significantly reduces intratesticular concentrations of retinoic acid and Stra8 expression and very severely suppresses spermatogenesis and fertility.

Category: Toxic substance.

Toxicity Grade: Highly toxic.

Acute Toxicity: Intraperitoneal in mice, LDL₀: 150 mg/kg.

Flammability Hazard: Combustible; upon heating, produces toxic nitrogen oxide and chloride fumes. Side effects: nausea, vomiting, altered spermatogenesis.

Storage and Transport: Store in a cool, dry, well-ventilated warehouse; keep separate from food raw materials.

Extinguishing Agents: Dry powder, foam, sand, carbon dioxide, water mist.

Category	Value
Hazard Symbol	Xn
Hazard Codes (R Phrases)	20/21/22-40
Safety Codes (S Phrases)	24/25-45-36
WGK Germany	WGK 3
Storage Category	11 - Combustible solids
Hazard Classification	Acute Toxicity Category 4 (Dermal), Acute Toxicity Category 4 (Inhalation), Carcinogenicity Category 2
Toxicity	LD50 orally in mice: >16000 mg/kg (Coulston)

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

CAS：1477-57-2 | N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) | Whchem

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N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE)

CAS：1477-57-2 | N,N'-OCTAMETHYLENEBIS(DICHLOROACETAMIDE) | Whchem

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