5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

Name: 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
Brand: Zhengzhou Whchem

CAS：171178-45-3 | 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE | Whchem

CAS: 171178-45-3

Other Names

5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine ,98%;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR;tert-butyl N-(6-chloropyridin-3-yl)carbamate;N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester;(6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester;5-tert-ButoxycarbonylaMino-2-chloropyridine;N-Boc-6-chloro-3-pyridinamine

Structure - 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

Molecular Formula

Purity

>97%

Molecular Weight

228.68 g/mol

EINECS

Structure Available Verified Product

English Name	5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE
English Synonyms	5-[N-(tert-Butoxycarbonyl)amino]-2-chloropyridine ,98%;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE;5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOR;tert-butyl N-(6-chloropyridin-3-yl)carbamate;N-(6-chloro-3-pyridinyl)carbamic acid tert-butyl ester;(6-chloro-pyridin-3-yl)-carbamic acid, tert-butyl ester;5-tert-ButoxycarbonylaMino-2-chloropyridine;N-Boc-6-chloro-3-pyridinamine
CAS Number	171178-45-3
Molecular Formula	C10H13ClN2O2
Molecular Weight	228.68 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	127-129°C
Boiling point	283.7±25.0 °C (Predicted)
Density	1.245±0.06 g/cm³ (Predicted)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Acidity Coefficient (pKa)	12.06±0.70 (Predicted)
Appearance	Pale brown to pale purple solid
InChI	InChI=1S/C10H13ClN2O2/c1-10(2,3)15-9(14)13-7-4-5-8(11)12-6-7/h4-6H,1-3H3,(H,13,14)
InChIKey	IRHNQVINMHHEIO-UHFFFAOYSA-N
SMILES	C(OC(C)(C)C)(=O)NC1=CC=C(Cl)N=C1

5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE (CAS 171178-45-3) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods tert-Butyl (6-Chloropyridin-3-yl)carbamate	Uses & Synthesis Methods Introduction: tert-Butyl (6-chloropyridin-3-yl)carbamate and its derivatives are a very useful class of aminopyridine derivatives that serve as important pharmaceutical intermediates. Preparation: A three-necked flask equipped with a stirring device was charged with 5-amino-2-chloropyridine and 200 mL of a buffer solution composed of sodium carbonate and sodium bicarbonate. The mixture was cooled in an ice bath, and di-tert-butyl dicarbonate was added dropwise via a dropping funnel. The reaction was stirred in a 30°C water bath for 22 hours. The reaction mixture was extracted with diethyl ether (100 mL × 2) to remove unreacted di-tert-butyl dicarbonate. The aqueous phase was adjusted to pH 2-3 with 3 mol/L aqueous hydrochloric acid, then extracted with ethyl acetate (100 mL × 4). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation to afford tert-butyl (6-chloropyridin-3-yl)carbamate as a colorless oil.

Category

Description (English Translation)

Uses & Synthesis Methods

tert-Butyl (6-Chloropyridin-3-yl)carbamate

Uses & Synthesis Methods

Introduction: tert-Butyl (6-chloropyridin-3-yl)carbamate and its derivatives are a very useful class of aminopyridine derivatives that serve as important pharmaceutical intermediates.

Preparation: A three-necked flask equipped with a stirring device was charged with 5-amino-2-chloropyridine and 200 mL of a buffer solution composed of sodium carbonate and sodium bicarbonate. The mixture was cooled in an ice bath, and di-tert-butyl dicarbonate was added dropwise via a dropping funnel. The reaction was stirred in a 30°C water bath for 22 hours. The reaction mixture was extracted with diethyl ether (100 mL × 2) to remove unreacted di-tert-butyl dicarbonate. The aqueous phase was adjusted to pH 2-3 with 3 mol/L aqueous hydrochloric acid, then extracted with ethyl acetate (100 mL × 4). The combined organic layers were dried over anhydrous sodium sulfate, filtered, and the solvent was removed by rotary evaporation to afford tert-butyl (6-chloropyridin-3-yl)carbamate as a colorless oil.

Category	Value
Hazard Class	IRRITANT
HS Code (Customs)	29333990

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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

CAS：171178-45-3 | 5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE | Whchem

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5-[N-(TERT-BUTOXYCARBONYL)AMINO]-2-CHLOROPYRIDINE

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