5,7-DIHYDROXYCOUMARIN

Name: 5,7-DIHYDROXYCOUMARIN
Brand: Zhengzhou Whchem

CAS：2732-18-5 | 5,7-DIHYDROXYCOUMARIN | Whchem

CAS: 2732-18-5

Other Names

5,7-DIHYDROXYCOUMARIN;2H-1-Benzopyran-2-one, 5,7-dihydroxy-;5,7-Dihydroxy-2H-1-benzopyran-2-one;5,7-Dihydroxy-2H-chromen-2-one;5,7-dihydroxy-1-benzopyran-2-one;5,7-dihydroxychromen-2-one;Inhibitor,5,7-Dihydroxycoumarin,antibacterial,Bacterial,inhibit,5,7Dihydroxycoumarin,5,7 Dihydroxycoumarin,coumarin;5,7-Dihydroxycoumarin, 10 mM in DMSO

Molecular Formula

Purity

>98%

Molecular Weight

178.14 g/mol

EINECS

Structure Available Verified Product

English Name	5,7-DIHYDROXYCOUMARIN
English Synonyms	5,7-DIHYDROXYCOUMARIN;2H-1-Benzopyran-2-one, 5,7-dihydroxy-;5,7-Dihydroxy-2H-1-benzopyran-2-one;5,7-Dihydroxy-2H-chromen-2-one;5,7-dihydroxy-1-benzopyran-2-one;5,7-dihydroxychromen-2-one;Inhibitor,5,7-Dihydroxycoumarin,antibacterial,Bacterial,inhibit,5,7Dihydroxycoumarin,5,7 Dihydroxycoumarin,coumarin;5,7-Dihydroxycoumarin, 10 mM in DMSO
CAS Number	2732-18-5
Molecular Formula	C9H6O4
Molecular Weight	178.14 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	280 °C
Boiling point	506.4±19.0 °C (Predicted)
Density	1.563±0.06 g/cm³ (Predicted)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Acidity Coefficient (pKa)	7.18±0.20 (Predicted)
Form	Solid
Color	Off-white to yellow

5,7-DIHYDROXYCOUMARIN (CAS 2732-18-5) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 5,7-DIHYDROXYCOUMARIN with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Biological Activity: 5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescence of Macaranga triloba, and exhibits antibacterial activity. Production Method: Starting Materials: 108-73-6 (Phloroglucinol) 471-25-0 (Propiolic acid) 2732-18-5 (5,7-Dihydroxy-2H-chromen-2-one) General procedure for the synthesis of 5,7-dihydroxy-2H-chromen-2-one from phloroglucinol and propiolic acid: A mixture of phloroglucinol (1.0 mmol), propiolic acid (1.1 mmol), and Yb(OTf)₃ hydrate (0.1 mmol) was placed in an open reaction vessel and irradiated in a microwave apparatus at 200 W (80°C) for 2 minutes. The progress of the reaction was monitored by thin-layer chromatography (TLC) using CH₂Cl₂/MeOH (99:1) as eluent. After completion, the crude product was diluted with diethyl ether (Et₂O). The resulting suspension was filtered under vacuum to separate the catalyst, and the precipitate was washed several times with ether. The filtrate was washed twice with 5% NaHCO₃ solution (10 mL), dried over anhydrous MgSO₄, and evaporated to dryness under vacuum to afford the desired product, 5,7-dihydroxy-2H-chromen-2-one. References: [1] Synlett, 1999, # 5, p. 608 - 610 [2] Tetrahedron Letters, 2016, vol. 57, # 26, p. 2939 - 2942 [3] Synthesis, 2011, # 8, p. 1283 - 1289 [4] Journal of Natural Medicines, 2017, vol. 71, # 4, p. 735 - 744

Category

Description (English Translation)

Uses & Synthesis Methods

Biological Activity: 5,7-Dihydroxycoumarin is a coumarin isolated from the inflorescence of Macaranga triloba, and exhibits antibacterial activity.

Production Method:

Starting Materials:
108-73-6 (Phloroglucinol)
471-25-0 (Propiolic acid)
2732-18-5 (5,7-Dihydroxy-2H-chromen-2-one)

General procedure for the synthesis of 5,7-dihydroxy-2H-chromen-2-one from phloroglucinol and propiolic acid:

A mixture of phloroglucinol (1.0 mmol), propiolic acid (1.1 mmol), and Yb(OTf)₃ hydrate (0.1 mmol) was placed in an open reaction vessel and irradiated in a microwave apparatus at 200 W (80°C) for 2 minutes. The progress of the reaction was monitored by thin-layer chromatography (TLC) using CH₂Cl₂/MeOH (99:1) as eluent. After completion, the crude product was diluted with diethyl ether (Et₂O). The resulting suspension was filtered under vacuum to separate the catalyst, and the precipitate was washed several times with ether. The filtrate was washed twice with 5% NaHCO₃ solution (10 mL), dried over anhydrous MgSO₄, and evaporated to dryness under vacuum to afford the desired product, 5,7-dihydroxy-2H-chromen-2-one.

References:
[1] Synlett, 1999, # 5, p. 608 - 610
[2] Tetrahedron Letters, 2016, vol. 57, # 26, p. 2939 - 2942
[3] Synthesis, 2011, # 8, p. 1283 - 1289
[4] Journal of Natural Medicines, 2017, vol. 71, # 4, p. 735 - 744

Category	Value
HS Code (Customs)	2932990090

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5,7-DIHYDROXYCOUMARIN

CAS：2732-18-5 | 5,7-DIHYDROXYCOUMARIN | Whchem

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