N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE

Name: N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE
Brand: Zhengzhou Whchem

CAS：2903-34-6 | N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE | Whchem

CAS: 2903-34-6

Other Names

n-(4-chlorophenyl)-4-methyl-benzenesulfonamid;N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE;N-(p-chlorophenyl)-p-toluenesulphonamide;N-(4-chlorophenyl)-p-toluenesulfonamide(pract);N-(4-Chlorophenyl)-4-methylbenzenesulfonamide;4-methyl-N-(4-chlorophenyl)benzenesulfonamide;Benzenesulfonamide, N-(4-chlorophenyl)-4-methyl-;4-Chlorophenyl toluenesulfonamide

Structure - N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE

Molecular Formula

Purity

>97%

Molecular Weight

281.76 g/mol

EINECS

Structure Available Verified Product

English Name	N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE
English Synonyms	n-(4-chlorophenyl)-4-methyl-benzenesulfonamid;N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE;N-(p-chlorophenyl)-p-toluenesulphonamide;N-(4-chlorophenyl)-p-toluenesulfonamide(pract);N-(4-Chlorophenyl)-4-methylbenzenesulfonamide;4-methyl-N-(4-chlorophenyl)benzenesulfonamide;Benzenesulfonamide, N-(4-chlorophenyl)-4-methyl-;4-Chlorophenyl toluenesulfonamide
CAS Number	2903-34-6
Molecular Formula	C13H12ClNO2S
Molecular Weight	281.76 g/mol
EINECS Number	z
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	118-122 °C
EPA Chemical Substance Reference	Benzenesulfonamide, N-(4-chlorophenyl)-4-methyl- (2903-34-6)

N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE (CAS 2903-34-6) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods N-(4-Chlorophenyl)-4-methylbenzenesulfonamide	Uses: This compound serves as a pharmaceutical intermediate[citation:2]. Notably, it exhibits significant antibacterial activity, with a reported MIC of 25 µM against Staphylococcus aureus, which is twice as potent as many other sulfonamide derivatives tested in the same panel[citation:7][citation:11]. It is also a key precursor in the synthesis of other compounds, such as 2,2-bis[4-(4-aminophenoxy)phenyl]propane[citation:5]. Synthesis Methods: It is synthesized by reacting 4-chloroaniline with p-toluenesulfonyl chloride in the presence of a base (e.g., pyridine) in a solvent like acetonitrile, with the reaction typically carried out at or below room temperature[citation:9][citation:10]. An alternative "green" synthesis route utilizes aqueous extracts of natural orange and banana peels as catalysts, achieving yields exceeding 90%[citation:11].

Category

Description (English Translation)

Uses & Synthesis Methods

N-(4-Chlorophenyl)-4-methylbenzenesulfonamide

Uses: This compound serves as a pharmaceutical intermediate[citation:2]. Notably, it exhibits significant antibacterial activity, with a reported MIC of 25 µM against Staphylococcus aureus, which is twice as potent as many other sulfonamide derivatives tested in the same panel[citation:7][citation:11]. It is also a key precursor in the synthesis of other compounds, such as 2,2-bis[4-(4-aminophenoxy)phenyl]propane[citation:5].

Synthesis Methods: It is synthesized by reacting 4-chloroaniline with p-toluenesulfonyl chloride in the presence of a base (e.g., pyridine) in a solvent like acetonitrile, with the reaction typically carried out at or below room temperature[citation:9][citation:10]. An alternative "green" synthesis route utilizes aqueous extracts of natural orange and banana peels as catalysts, achieving yields exceeding 90%[citation:11].

Category	Value
Safety Codes (S Phrases)	24/25
TSCA	TSCA listed

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N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE

CAS：2903-34-6 | N-(4-CHLOROPHENYL)-P-TOLUENESULFONAMIDE | Whchem

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