2,3-BIS(BROMOMETHYL)QUINOXALINE

Name: 2,3-BIS(BROMOMETHYL)QUINOXALINE
Brand: Zhengzhou Whchem

CAS：3138-86-1 | 2,3-BIS(BROMOMETHYL)QUINOXALINE | Whchem

CAS: 3138-86-1

Other Names

2,3-BIS(BROMOMETHYL)QUINOXALINE;2,3-BIS-(BROMETHYL)-QUINOXALINE98%;2,3-bis(bromomethyl)-quinoxalin;2,3-Bis-(bromomethyl)quinoxaline, HPLC 98%;2,3-Bis(bromomethyl)quinoxaline,98%;2,3-Bis(bromomethyl)-1,4-benzodiazine;NSC 38602;2,3-BIS-(BROMETHYL)QUINOXALINE

Structure - 2,3-BIS(BROMOMETHYL)QUINOXALINE

Molecular Formula

Purity

>97%

Molecular Weight

315.99 g/mol

EINECS

221-538-4

Structure Available Verified Product

English Name	2,3-BIS(BROMOMETHYL)QUINOXALINE
English Synonyms	2,3-BIS(BROMOMETHYL)QUINOXALINE;2,3-BIS-(BROMETHYL)-QUINOXALINE98%;2,3-bis(bromomethyl)-quinoxalin;2,3-Bis-(bromomethyl)quinoxaline, HPLC 98%;2,3-Bis(bromomethyl)quinoxaline,98%;2,3-Bis(bromomethyl)-1,4-benzodiazine;NSC 38602;2,3-BIS-(BROMETHYL)QUINOXALINE
CAS Number	3138-86-1
Molecular Formula	C10H8Br2N2
Molecular Weight	315.99 g/mol
EINECS Number	221-538-4
Related Categories	Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Quinoxalines;QuinoxalinesHeterocyclic Building Blocks
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	152-156 °C (lit.)
Boiling point	345.7±37.0 °C (Predicted)
Density	1.7904 (rough estimate)
Refractive index	1.7040 (estimate)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Acidity Coefficient (pKa)	-1.31±0.48 (Predicted)
Form	Powder
Appearance	Off-white to gray solid
InChI	InChI=1S/C10H8Br2N2/c11-5-9-10(6-12)14-8-4-2-1-3-7(8)13-9/h1-4H,5-6H2
InChIKey	LHKFFORGJVELPC-UHFFFAOYSA-N
SMILES	BrCc1nc2ccccc2nc1CBr
EPA Chemical Substance Reference	Quinoxaline, 2,3-bis(bromomethyl)- (3138-86-1)

2,3-BIS(BROMOMETHYL)QUINOXALINE (CAS 3138-86-1) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 2,3-BIS(BROMOMETHYL)QUINOXALINE with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Production Method: Starting Materials: 95-54-5 (o-Phenylenediamine) 6305-43-7 (1,4-Dibromo-2,3-butanedione) 3138-86-1 (2,3-Bis(bromomethyl)quinoxaline) The general procedure for synthesizing 2,3-bis(bromomethyl)quinoxaline from o-phenylenediamine and 1,4-dibromo-2,3-butanedione is as follows: 6.52 g (27 mmol) of 1,4-dibromo-2,3-butanedione and 300 mL of ethanol were added to a 1,000 mL three-necked flask. Subsequently, a solution prepared from 2.94 g (27 mmol) of o-phenylenediamine dissolved in 150 mL of ethanol was added to the mixture. The mixture was stirred at room temperature for 30 minutes. During the reaction, a white solid precipitate was observed. 200 mL of water was added to the reaction mixture. The white solid was collected by suction filtration and dried under reduced pressure to obtain 6.74 g (81% yield) of the target product, 2,3-bis(bromomethyl)quinoxaline. 1H-NMR (CDCl₃): δ 4.93 (s, 4H), 7.81 (q, 2H), 8.08 (q, 2H). References: [1] Tetrahedron, 2013, vol. 69, # 4, p. 1403 - 1416 [2] Journal of Organic Chemistry, 2005, vol. 70, # 13, p. 5055 - 5061 [3] Organometallics, 2013, vol. 32, # 12, p. 3493 - 3501 [4] Synthetic Communications, 2011, vol. 41, # 3, p. 417 - 425 [5] Journal of Chemical Crystallography, 2006, vol. 36, # 3, p. 211 - 215 Category: Toxic substance. Toxicity Grade: Highly toxic. Acute Toxicity: Intravenous in mice, LD50: 18 mg/kg. Flammability Hazard: Combustible; produces toxic nitrogen oxide and bromide fumes upon combustion. Storage and Transport: Store in a cool, dry, well-ventilated warehouse; keep separate from food raw materials. Extinguishing Agents: Dry powder, foam, sand, carbon dioxide, water mist.

Category

Description (English Translation)

Uses & Synthesis Methods

Production Method:

Starting Materials:
95-54-5 (o-Phenylenediamine)
6305-43-7 (1,4-Dibromo-2,3-butanedione)
3138-86-1 (2,3-Bis(bromomethyl)quinoxaline)

The general procedure for synthesizing 2,3-bis(bromomethyl)quinoxaline from o-phenylenediamine and 1,4-dibromo-2,3-butanedione is as follows:

6.52 g (27 mmol) of 1,4-dibromo-2,3-butanedione and 300 mL of ethanol were added to a 1,000 mL three-necked flask. Subsequently, a solution prepared from 2.94 g (27 mmol) of o-phenylenediamine dissolved in 150 mL of ethanol was added to the mixture. The mixture was stirred at room temperature for 30 minutes. During the reaction, a white solid precipitate was observed. 200 mL of water was added to the reaction mixture. The white solid was collected by suction filtration and dried under reduced pressure to obtain 6.74 g (81% yield) of the target product, 2,3-bis(bromomethyl)quinoxaline.

1H-NMR (CDCl₃): δ 4.93 (s, 4H), 7.81 (q, 2H), 8.08 (q, 2H).

References:
[1] Tetrahedron, 2013, vol. 69, # 4, p. 1403 - 1416
[2] Journal of Organic Chemistry, 2005, vol. 70, # 13, p. 5055 - 5061
[3] Organometallics, 2013, vol. 32, # 12, p. 3493 - 3501
[4] Synthetic Communications, 2011, vol. 41, # 3, p. 417 - 425
[5] Journal of Chemical Crystallography, 2006, vol. 36, # 3, p. 211 - 215

Category: Toxic substance.

Toxicity Grade: Highly toxic.

Acute Toxicity: Intravenous in mice, LD50: 18 mg/kg.

Flammability Hazard: Combustible; produces toxic nitrogen oxide and bromide fumes upon combustion.

Storage and Transport: Store in a cool, dry, well-ventilated warehouse; keep separate from food raw materials.

Extinguishing Agents: Dry powder, foam, sand, carbon dioxide, water mist.

Category	Value
Hazard Symbol	C
Hazard Codes (R Phrases)	34-36/37
Safety Codes (S Phrases)	26-27-28-36/37/39-45
UN Number	UN 3261 8/PG 2
WGK Germany	3
RTECS Number	VD1420000
TSCA	TSCA listed
Hazard Class	8
Packing Group	III
Storage Category	8A - Flammable, corrosive substances
Hazard Classification	Serious Eye Damage Category 1, Skin Corrosion Category 1B, Specific Target Organ Toxicity - Single Exposure Category 3
Toxicity	LD50 ivn-mus: 18 mg/kg CSLNX* NX#02400

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2,3-BIS(BROMOMETHYL)QUINOXALINE

CAS：3138-86-1 | 2,3-BIS(BROMOMETHYL)QUINOXALINE | Whchem

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2,3-BIS(BROMOMETHYL)QUINOXALINE

CAS：3138-86-1 | 2,3-BIS(BROMOMETHYL)QUINOXALINE | Whchem

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