8-BROMO-2H-1-BENZOPYRAN-2-ONE

Name: 8-BROMO-2H-1-BENZOPYRAN-2-ONE
Brand: Zhengzhou Whchem

CAS：33491-30-4 | 8-BROMO-2H-1-BENZOPYRAN-2-ONE | Whchem

CAS: 33491-30-4

Other Names

8-BROMO-2H-1-BENZOPYRAN-2-ONE;8-BroMo-2H-chroMen-2-one;8-Bromochromen-2-one;2H-1-Benzopyran-2-one, 8-bromo-;8-bromocoumarin

Structure - 8-BROMO-2H-1-BENZOPYRAN-2-ONE

Molecular Formula

Purity

>98%

Molecular Weight

225.04 g/mol

EINECS

202-110-6

Structure Available Verified Product

English Name	8-BROMO-2H-1-BENZOPYRAN-2-ONE
English Synonyms	8-BROMO-2H-1-BENZOPYRAN-2-ONE;8-BroMo-2H-chroMen-2-one;8-Bromochromen-2-one;2H-1-Benzopyran-2-one, 8-bromo-;8-bromocoumarin
CAS Number	33491-30-4
Molecular Formula	C9H5BrO2
Molecular Weight	225.04 g/mol
EINECS Number	202-110-6
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	135-136 °C (Solv: methanol (67-56-1))
Boiling point	352.2±37.0 °C (Predicted)
Density	1.688±0.06 g/cm³ (Predicted)
Storage condition	Sealed in dry, Room Temperature

8-BROMO-2H-1-BENZOPYRAN-2-ONE (CAS 33491-30-4) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 8-BROMO-2H-1-BENZOPYRAN-2-ONE with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Production Method: Starting Materials: 1829-34-1 (3-Bromo-2-hydroxybenzaldehyde) 33491-30-4 (8-Bromo-2H-1-benzopyran-2-one) Starting from 3-bromo-2-hydroxybenzaldehyde (402 mg, 2.0 mmol), it was dissolved in N-methylpyrrolidone (NMP, 5 mL). Ethoxycarbonylmethylenetriphenylphosphorane (765 mg, 2.2 mmol) was then added to the solution. The reaction mixture was heated at 210°C for 3 hours. After completion, the mixture was cooled to room temperature and then partitioned between water and ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate (MgSO₄). The product was purified by silica gel flash column chromatography (eluent: 2:1 hexane/ethyl acetate) to afford 8-bromo-2H-1-benzopyran-2-one (116 mg, 26% yield) as a pale beige solid. Mass spectrometry (electrospray ionization, ES) showed m/e 227.0 ([M + H]⁺). References: [1] Patent: WO2007/118130, 2007, A2. Location in patent: Page/Page column 28-29 [2] Heterocycles, 2003, vol. 59, # 1, p. 217 - 224

Category

Description (English Translation)

Uses & Synthesis Methods

Production Method:

Starting Materials:
1829-34-1 (3-Bromo-2-hydroxybenzaldehyde)
33491-30-4 (8-Bromo-2H-1-benzopyran-2-one)

Starting from 3-bromo-2-hydroxybenzaldehyde (402 mg, 2.0 mmol), it was dissolved in N-methylpyrrolidone (NMP, 5 mL). Ethoxycarbonylmethylenetriphenylphosphorane (765 mg, 2.2 mmol) was then added to the solution. The reaction mixture was heated at 210°C for 3 hours. After completion, the mixture was cooled to room temperature and then partitioned between water and ethyl acetate. The organic layer was separated and dried over anhydrous magnesium sulfate (MgSO₄). The product was purified by silica gel flash column chromatography (eluent: 2:1 hexane/ethyl acetate) to afford 8-bromo-2H-1-benzopyran-2-one (116 mg, 26% yield) as a pale beige solid. Mass spectrometry (electrospray ionization, ES) showed m/e 227.0 ([M + H]⁺).

References:
[1] Patent: WO2007/118130, 2007, A2. Location in patent: Page/Page column 28-29
[2] Heterocycles, 2003, vol. 59, # 1, p. 217 - 224

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8-BROMO-2H-1-BENZOPYRAN-2-ONE

CAS：33491-30-4 | 8-BROMO-2H-1-BENZOPYRAN-2-ONE | Whchem

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