2-AMINO-5-CHLOROBENZYL ALCOHOL

Name: 2-AMINO-5-CHLOROBENZYL ALCOHOL
Brand: Zhengzhou Whchem

CAS：37585-25-4 | 2-AMINO-5-CHLOROBENZYL ALCOHOL | Whchem

CAS: 37585-25-4

Other Names

RARECHEM AL BD 1516;(2-AMINO-5-CHLOROPHENYL)METHANOL;2-AMINO-5-CHLOROBENZYL ALCOHOL;2-Amino-5-chlorobenzenemethanol;Benzenemethanol, 2-amino-5-chloro-;2-AMINO-5-CHLOROBENZYL ALCOHOL USP/EP/BP;SKL307

Structure - 2-AMINO-5-CHLOROBENZYL ALCOHOL

Molecular Formula

Purity

>98%

Molecular Weight

157.6 g/mol

EINECS

Structure Available Verified Product

English Name	2-AMINO-5-CHLOROBENZYL ALCOHOL
English Synonyms	RARECHEM AL BD 1516;(2-AMINO-5-CHLOROPHENYL)METHANOL;2-AMINO-5-CHLOROBENZYL ALCOHOL;2-Amino-5-chlorobenzenemethanol;Benzenemethanol, 2-amino-5-chloro-;2-AMINO-5-CHLOROBENZYL ALCOHOL USP/EP/BP;SKL307
CAS Number	37585-25-4
Molecular Formula	C7H8ClNO
Molecular Weight	157.6 g/mol
EINECS Number
Related Categories	Amino Alcohols;Organic Building Blocks;Oxygen Compounds
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	107-109 °C (lit.)
Boiling point	320.7±27.0 °C (Predicted)
Density	1.341±0.06 g/cm³ (Predicted)
Storage condition	Keep in dark place, Inert atmosphere, Room temperature
Acidity Coefficient (pKa)	13.94±0.10 (Predicted)
Appearance	White to off-white solid

2-AMINO-5-CHLOROBENZYL ALCOHOL (CAS 37585-25-4) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 2-AMINO-5-CHLOROBENZYL ALCOHOL with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Application: 2-Amino-5-chlorobenzyl alcohol can be used as an organic synthesis intermediate and pharmaceutical intermediate. It is mainly used in laboratory research and development, as well as in chemical production processes. Production Method: Starting Materials: 635-21-2 (2-Amino-5-chlorobenzoic acid) 37585-25-4 (2-Amino-5-chlorobenzyl alcohol) General Procedure: At room temperature, 2-amino-5-chlorobenzoic acid (8.5 mmol) was dissolved in THF (24 mL) to prepare a solution. This solution was added dropwise over 20 minutes to a suspension of lithium aluminum hydride (20.4 mmol) in THF (10 mL). The reaction mixture was stirred at room temperature for 3.5 hours. Subsequently, water (10 mL) was slowly added at 0°C to quench the reaction. The resulting suspension was filtered through a Celite plug and washed with EtOAc (100 mL). The organic phase was washed with brine (30 mL), dried over anhydrous MgSO₄, and finally concentrated under vacuum to afford 2-amino-5-chlorobenzyl alcohol. References: [1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624 [2] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222 [3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799 [4] Patent: WO2010/37533, 2010, A1. Location in patent: Page/Page column 44 [5] Organic Letters, 2016, vol. 18, # 21, p. 5572 - 5575

Category

Description (English Translation)

Uses & Synthesis Methods

Application: 2-Amino-5-chlorobenzyl alcohol can be used as an organic synthesis intermediate and pharmaceutical intermediate. It is mainly used in laboratory research and development, as well as in chemical production processes.

Production Method:

Starting Materials:
635-21-2 (2-Amino-5-chlorobenzoic acid)
37585-25-4 (2-Amino-5-chlorobenzyl alcohol)

General Procedure: At room temperature, 2-amino-5-chlorobenzoic acid (8.5 mmol) was dissolved in THF (24 mL) to prepare a solution. This solution was added dropwise over 20 minutes to a suspension of lithium aluminum hydride (20.4 mmol) in THF (10 mL). The reaction mixture was stirred at room temperature for 3.5 hours. Subsequently, water (10 mL) was slowly added at 0°C to quench the reaction. The resulting suspension was filtered through a Celite plug and washed with EtOAc (100 mL). The organic phase was washed with brine (30 mL), dried over anhydrous MgSO₄, and finally concentrated under vacuum to afford 2-amino-5-chlorobenzyl alcohol.

References:
[1] ACS Catalysis, 2013, vol. 3, # 4, p. 622 - 624
[2] Organic Letters, 2017, vol. 19, # 12, p. 3219 - 3222
[3] Tetrahedron Letters, 2017, vol. 58, # 40, p. 3795 - 3799
[4] Patent: WO2010/37533, 2010, A1. Location in patent: Page/Page column 44
[5] Organic Letters, 2016, vol. 18, # 21, p. 5572 - 5575

Category	Value
Hazard Symbol	Xi
Hazard Codes (R Phrases)	36/37/38
Safety Codes (S Phrases)	26-37/39
WGK Germany	3

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2-AMINO-5-CHLOROBENZYL ALCOHOL

CAS：37585-25-4 | 2-AMINO-5-CHLOROBENZYL ALCOHOL | Whchem

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