3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)

Name: 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)
Brand: Zhengzhou Whchem

CAS：395652-44-5 | 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI) | Whchem

CAS: 395652-44-5

Other Names

3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI);4-(Pyridin-2-yl)but-3-yn-1-ol;4-(2-Pyridyl)-3-butyn-1-ol;4-(2-pyridinyl)-3-Butyn-1-ol;3-Butyn-1-ol, 4-(2-pyridinyl)-;3-BUTYN-1-OL,4-(PYRIDIN-2-YL)-;Name:?4-pyridin-2-ylbut-3-yn-1-ol

Structure - 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)

Molecular Formula

Purity

>97%

Molecular Weight

147.17 g/mol

EINECS

Structure Available Verified Product

English Name	3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)
English Synonyms	3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI);4-(Pyridin-2-yl)but-3-yn-1-ol;4-(2-Pyridyl)-3-butyn-1-ol;4-(2-pyridinyl)-3-Butyn-1-ol;3-Butyn-1-ol, 4-(2-pyridinyl)-;3-BUTYN-1-OL,4-(PYRIDIN-2-YL)-;Name:?4-pyridin-2-ylbut-3-yn-1-ol
CAS Number	395652-44-5
Molecular Formula	C9H9NO
Molecular Weight	147.17 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Boiling point	301.4±22.0 °C (Predicted)
Density	1.13±0.1 g/cm³ (Predicted)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Acidity Coefficient (pKa)	14.24±0.10 (Predicted)

3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI) (CAS 395652-44-5) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI) with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Production Method: Starting Materials: 5029-67-4 (2-Iodopyridine) 927-74-2 (3-Butyn-1-ol) 395652-44-5 (4-(Pyridin-2-yl)but-3-yn-1-ol) In a sealed tube, 2-iodopyridine (1 mmol, 1 equiv), K₃PO₄ (2 mmol, 2 equiv), and palladium catalyst (2 mol%) were suspended in a mixed solvent of isopropanol (3 mL) and water (3 mL). 3-Butyn-1-ol (1.2 mmol, 1.2 equiv) was then added, and the reaction mixture was stirred at 80°C for 20 hours. After the reaction was complete, the mixture was cooled to room temperature, diluted with ethyl acetate (20 mL) and water (20 mL), and then filtered. The aqueous phase was extracted twice with ethyl acetate (2 × 20 mL). The combined organic phases were washed with saturated brine (60 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash column chromatography. References: [1] Applied Catalysis A: General, 2014, vol. 482, p. 157 - 162

Category

Description (English Translation)

Uses & Synthesis Methods

Production Method:

Starting Materials:
5029-67-4 (2-Iodopyridine)
927-74-2 (3-Butyn-1-ol)
395652-44-5 (4-(Pyridin-2-yl)but-3-yn-1-ol)

In a sealed tube, 2-iodopyridine (1 mmol, 1 equiv), K₃PO₄ (2 mmol, 2 equiv), and palladium catalyst (2 mol%) were suspended in a mixed solvent of isopropanol (3 mL) and water (3 mL). 3-Butyn-1-ol (1.2 mmol, 1.2 equiv) was then added, and the reaction mixture was stirred at 80°C for 20 hours. After the reaction was complete, the mixture was cooled to room temperature, diluted with ethyl acetate (20 mL) and water (20 mL), and then filtered. The aqueous phase was extracted twice with ethyl acetate (2 × 20 mL). The combined organic phases were washed with saturated brine (60 mL), dried over anhydrous magnesium sulfate, filtered, and concentrated under reduced pressure. The crude product was purified by flash column chromatography.

References:
[1] Applied Catalysis A: General, 2014, vol. 482, p. 157 - 162

Category	Value
HS Code (Customs)	2933399990

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3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)

CAS：395652-44-5 | 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI) | Whchem

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3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI)

CAS：395652-44-5 | 3-Butyn-1-ol, 4-(2-pyridinyl)- (9CI) | Whchem

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