4-METHYLESCULETIN

Name: 4-METHYLESCULETIN
Brand: Zhengzhou Whchem

CAS：529-84-0 | 4-METHYLESCULETIN | Whchem

CAS: 529-84-0

Other Names

4-METHYLESCULETIN;6,7-DIHYDROXY-4-METHYL-CHROMEN-2-ONE;6,7-DIHYDROXY-4-METHYLCOUMARIN;METHYLESCULETIN, 4-;methylesculetin;6 7-DIHYDROXY-4-METHYLCOUMARIN FOR &;4-Methylesculetin, 98+%;(6,7-Dihydroxy-4-methylcoumarin)4-Methylesculetin

Molecular Formula

Purity

>97%

Molecular Weight

192.17 g/mol

EINECS

208-470-0

Structure Available Verified Product

English Name	4-METHYLESCULETIN
English Synonyms	4-METHYLESCULETIN;6,7-DIHYDROXY-4-METHYL-CHROMEN-2-ONE;6,7-DIHYDROXY-4-METHYLCOUMARIN;METHYLESCULETIN, 4-;methylesculetin;6 7-DIHYDROXY-4-METHYLCOUMARIN FOR &;4-Methylesculetin, 98+%;(6,7-Dihydroxy-4-methylcoumarin)4-Methylesculetin
CAS Number	529-84-0
Molecular Formula	C10H8O4
Molecular Weight	192.17 g/mol
EINECS Number	208-470-0
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	274-276 °C (lit.)
Boiling point	248.14°C (rough estimate)
Density	1.0825 (rough estimate)
Refractive index	1.4440 (estimate)
Storage condition	Sealed in dry, 2-8°C
Solubility	Soluble in DMF
Acidity Coefficient (pKa)	8.72 (at 25°C)
Form	Powder
Color	Light brown
pH Indicator Color Change Range	Colorless (4.0) to blue fluorescent (6.2)
Maximum Wavelength (λmax)	348 nm, 292 nm
BRN	162550
Major applications	Electroluminescent device, photoresists, photography, analytical reagent, cosmetics, hair dye, shampoo, antioxidant, hypotensive agent, antiinflammatory agent, antiviral agent, multidrug resistance (MDR) modulator, inhibitory effect on melanin biosynthesis, protective agent against DNA damage, antimutagenic agent, detection of tumor cell-specific cytotoxicity, antiproliferative against cancer cells, analysis of human pancreatic cancer cell activity, chondroprotective agent
LogP	0.959 (est)
CAS Database Reference	529-84-0 (CAS DataBase Reference)
EPA Chemical Substance Reference	4-Methylesculetin (529-84-0)

4-METHYLESCULETIN (CAS 529-84-0) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 4-METHYLESCULETIN with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Biological Activity: 4-Methylesculetin is a coumarin derivative with potent antioxidant and anti-inflammatory activities. 4-Methylesculetin can inhibit myeloperoxidase (MPO) activity and reduce IL-6 levels. Targets: MPO, IL-6. Chemical Properties: Yellow needle-like crystals. Melting point: 272-274°C. Soluble in hot water, alcohol, acetic acid, concentrated sulfuric acid, and dilute alkali, giving a blue fluorescence in solution. Ferric chloride gives a green color. Uses: Used as a fluorescent indicator. Production Method: Phenyl triacetate is prepared from benzoquinone and acetic anhydride in the presence of concentrated acid. This is then reacted with ethyl acetoacetate in dilute sulfuric acid. The reaction mixture is poured into ice water to precipitate crude 4-methylesculetin. The filtered crystals are recrystallized from water to give the final product.

Category

Description (English Translation)

Uses & Synthesis Methods

Biological Activity: 4-Methylesculetin is a coumarin derivative with potent antioxidant and anti-inflammatory activities. 4-Methylesculetin can inhibit myeloperoxidase (MPO) activity and reduce IL-6 levels.

Targets: MPO, IL-6.

Chemical Properties: Yellow needle-like crystals. Melting point: 272-274°C. Soluble in hot water, alcohol, acetic acid, concentrated sulfuric acid, and dilute alkali, giving a blue fluorescence in solution. Ferric chloride gives a green color.

Uses: Used as a fluorescent indicator.

Production Method: Phenyl triacetate is prepared from benzoquinone and acetic anhydride in the presence of concentrated acid. This is then reacted with ethyl acetoacetate in dilute sulfuric acid. The reaction mixture is poured into ice water to precipitate crude 4-methylesculetin. The filtered crystals are recrystallized from water to give the final product.

Category	Value
Hazard Symbol	Xi
Hazard Codes (R Phrases)	36/37/38
Safety Codes (S Phrases)	26-36
WGK Germany	2
RTECS Number	GN6384500
F (Hazard Index)	8
TSCA	TSCA listed
Hazard Class	IRRITANT
HS Code (Customs)	29322985

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4-METHYLESCULETIN

CAS：529-84-0 | 4-METHYLESCULETIN | Whchem

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