7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

Name: 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
Brand: Zhengzhou Whchem

CAS：575-03-1 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN | Whchem

CAS: 575-03-1

Other Names

TIMTEC-BB SBB006559;TFMU;TRIFLUOROMETHYLUMBELLIFERONE;7-HYDROXY-4-TRIFLUOROMETHYL-CHROMEN-2-ONE;7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN;7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;4-(TRIFLUOROMETHYL)UMBELLIFERON;4-(TRIFLUOROMETHYL)UMBELLIFERONE

Structure - 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

Molecular Formula

Purity

>98%

Molecular Weight

230.14 g/mol

EINECS

124-586-5

Structure Available Verified Product

English Name	7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN
English Synonyms	TIMTEC-BB SBB006559;TFMU;TRIFLUOROMETHYLUMBELLIFERONE;7-HYDROXY-4-TRIFLUOROMETHYL-CHROMEN-2-ONE;7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN;7-HYDROXY-4-(TRIFLUOROMETHYL)-2H-CHROMEN-2-ONE;4-(TRIFLUOROMETHYL)UMBELLIFERON;4-(TRIFLUOROMETHYL)UMBELLIFERONE
CAS Number	575-03-1
Molecular Formula	C10H5F3O3
Molecular Weight	230.14 g/mol
EINECS Number	124-586-5
Related Categories	Biochemicals and Reagents;Detection;Fluorescent Probes, Labels, Particles and Stains;Coumarins;Coumarin;API intermediates
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	178-180 °C (lit.)
Boiling point	311.4±42.0 °C (Predicted)
Density	1.4435 (estimate)
Storage condition	Sealed in dry, Room Temperature
Solubility	Soluble in DMF
Form	Powder crystals
Acidity Coefficient (pKa)	7.23±0.20 (Predicted)
Color	White to pale yellow to light orange
Maximum Wavelength (λmax)	330 nm (Toluene) (lit.)
BRN	210932
InChI	InChI=1S/C10H5F3O3/c11-10(12,13)7-4-9(15)16-8-3-5(14)1-2-6(7)8/h1-4,14H
InChIKey	CCKWMCUOHJAVOL-UHFFFAOYSA-N
SMILES	C1(=O)OC2=CC(O)=CC=C2C(C(F)(F)F)=C1

7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN (CAS 575-03-1) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods 7-Hydroxy-4-(trifluoromethyl)coumarin	Uses & Synthesis Methods Introduction: Studies have shown that 7-hydroxy-4-(trifluoromethyl)coumarin derivatives exhibit significant improvements in water solubility and antibacterial activity compared to 4-methyl-7-hydroxycoumarin derivatives. They show good antifungal activity against rice sheath blight fungus, cucumber anthracnose fungus, strawberry gray mold fungus, wheat head blight fungus, apple spot fungus, and tomato early blight fungus. They possess broad-spectrum antifungal activity and are expected to be developed into promising antifungal agents. Preparation Method: 3-Hydroxyphenol (11 g, 100 mmol) and ethyl trifluoroacetoacetate (15 mL, 100 mmol) are added to concentrated phosphoric acid (52 mL, 85%). After stirring at room temperature for 12 hours, the reaction mixture is poured into 150 mL of water. The crude product is collected by filtration and purified by recrystallization from ethanol. Uses: Suitable for use as a pH indicator.

Category

Description (English Translation)

Uses & Synthesis Methods

7-Hydroxy-4-(trifluoromethyl)coumarin

Uses & Synthesis Methods

Introduction: Studies have shown that 7-hydroxy-4-(trifluoromethyl)coumarin derivatives exhibit significant improvements in water solubility and antibacterial activity compared to 4-methyl-7-hydroxycoumarin derivatives. They show good antifungal activity against rice sheath blight fungus, cucumber anthracnose fungus, strawberry gray mold fungus, wheat head blight fungus, apple spot fungus, and tomato early blight fungus. They possess broad-spectrum antifungal activity and are expected to be developed into promising antifungal agents.

Preparation Method: 3-Hydroxyphenol (11 g, 100 mmol) and ethyl trifluoroacetoacetate (15 mL, 100 mmol) are added to concentrated phosphoric acid (52 mL, 85%). After stirring at room temperature for 12 hours, the reaction mixture is poured into 150 mL of water. The crude product is collected by filtration and purified by recrystallization from ethanol.

Uses: Suitable for use as a pH indicator.

Category	Value
Hazard Symbol	Xi, T
Hazard Codes (R Phrases)	36/37/38-25
Safety Codes (S Phrases)	26-36-45
UN Number	UN 2811 6.1/PG 3
WGK Germany	3
F (Hazard Index)	8-10
Hazard Class	IRRITANT
HS Code (Customs)	29322090
Storage Category	6.1A - Flammable, Acute Toxic Substances (Category 1 and 2) - Highly Dangerous Toxic Substances
Hazard Classification	Acute Toxicity Category 2 (Oral), Eye Irritation Category 2, Dermal Irritation Category 2, Specific Target Organ Toxicity - Single Exposure Category 3

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7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

CAS：575-03-1 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN | Whchem

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7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN

CAS：575-03-1 | 7-HYDROXY-4-(TRIFLUOROMETHYL)COUMARIN | Whchem

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