6-Methylquinoxaline

Name: 6-Methylquinoxaline
Brand: Zhengzhou Whchem

CAS：6344-72-5 | 6-Methylquinoxaline | Whchem

CAS: 6344-72-5

Other Names

6-METHYLQUINOXALINE;Quinoxaline, 6-methyl-;6-METHYLQUINOXALINE 99%;6-Methylquinoxaline , 97+%

Molecular Formula

Purity

>98%

Molecular Weight

144.17 g/mol

EINECS

Structure Available Verified Product

English Name	6-Methylquinoxaline
English Synonyms	6-METHYLQUINOXALINE;Quinoxaline, 6-methyl-;6-METHYLQUINOXALINE 99%;6-Methylquinoxaline , 97+%
CAS Number	6344-72-5
Molecular Formula	C9H8N2
Molecular Weight	144.17 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Melting point	218.5°C
Boiling point	244-245°C
Density	1.1164
Refractive index	1.6190
Flash point	244-245°C
Storage condition	Sealed in dry, Room Temperature
Acidity Coefficient (pKa)	1.40±0.30 (Predicted)
Appearance	Pale yellow to brown liquid
BRN	113371
InChI	InChI=1S/C9H8N2/c1-7-2-3-8-9(6-7)11-5-4-10-8/h2-6H,1H3
InChIKey	OSRARURJYPOUOV-UHFFFAOYSA-N
SMILES	N1C2C(=CC(C)=CC=2)N=CC=1
LogP	1.872 (est)
CAS Database Reference	6344-72-5 (CAS DataBase Reference)
NIST Chemistry WebBook Reference	Quinoxaline, 6-methyl- (6344-72-5)

6-Methylquinoxaline (CAS 6344-72-5) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 6-Methylquinoxaline with >98% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Overview: Quinoxaline and its derivatives are important chemical intermediates and are widely used in the fields of medicine, pesticides, feed, and dyes. In recent years, many research results have shown that 6-methylquinoxaline exhibits certain pharmacological activities in the treatment of obesity, antitumor, and other areas, showing research value and application prospects, attracting considerable attention. Efficacy and Effects: 6-Methylquinoxaline may bring significant breakthroughs in inhibiting or killing cancer cells, which has also prompted further research into the synthesis and antitumor activity of quinoxaline derivatives. Production Method: Starting Materials: 517-21-5 (Glyoxal) 496-72-0 (3,4-Diaminotoluene) 6344-72-5 (6-Methylquinoxaline) Synthesis of 6-Methylquinoxaline: 3,4-Diaminotoluene (Aldrich, 100 g, 0.82 mol) is dissolved in 600 mL of hot water (70-75°C) and quickly added to a slurry of glyoxal-sodium bisulfite adduct (Aldrich, 239.5 g, 0.9 mol, 1.1 equiv) in 400 mL of water at 60°C. The reaction mixture is heated at 60°C for 1 hour, then an additional 5 g (0.02 mol) of glyoxal adduct is added. After cooling to room temperature, the mixture is filtered through a paper filter. The filtrate is neutralized to pH 7.5-7.8 with 5 M aqueous NaOH and then extracted with diethyl ether (4 × 400 mL). The combined organic phases are dried over anhydrous Na₂SO₄ and concentrated by rotary evaporation to give 92 g of a brown oil. The crude product is purified by vacuum distillation (bp 100-102°C, 10 mmHg; literature value: 86°C, 1 mmHg) to afford 89 g (75% yield) of the desired product as a pale yellow oil. References: [1] Patent: US2005/282820, 2005, A1. Location in patent: Page/Page column 17-18 [2] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 7, p. 803 - 810 [3] Journal of the American Chemical Society, 1947, vol. 69, p. 795,796

Category

Description (English Translation)

Uses & Synthesis Methods

Overview: Quinoxaline and its derivatives are important chemical intermediates and are widely used in the fields of medicine, pesticides, feed, and dyes. In recent years, many research results have shown that 6-methylquinoxaline exhibits certain pharmacological activities in the treatment of obesity, antitumor, and other areas, showing research value and application prospects, attracting considerable attention.

Efficacy and Effects: 6-Methylquinoxaline may bring significant breakthroughs in inhibiting or killing cancer cells, which has also prompted further research into the synthesis and antitumor activity of quinoxaline derivatives.

Production Method:

Starting Materials:
517-21-5 (Glyoxal)
496-72-0 (3,4-Diaminotoluene)
6344-72-5 (6-Methylquinoxaline)

Synthesis of 6-Methylquinoxaline: 3,4-Diaminotoluene (Aldrich, 100 g, 0.82 mol) is dissolved in 600 mL of hot water (70-75°C) and quickly added to a slurry of glyoxal-sodium bisulfite adduct (Aldrich, 239.5 g, 0.9 mol, 1.1 equiv) in 400 mL of water at 60°C. The reaction mixture is heated at 60°C for 1 hour, then an additional 5 g (0.02 mol) of glyoxal adduct is added. After cooling to room temperature, the mixture is filtered through a paper filter. The filtrate is neutralized to pH 7.5-7.8 with 5 M aqueous NaOH and then extracted with diethyl ether (4 × 400 mL). The combined organic phases are dried over anhydrous Na₂SO₄ and concentrated by rotary evaporation to give 92 g of a brown oil. The crude product is purified by vacuum distillation (bp 100-102°C, 10 mmHg; literature value: 86°C, 1 mmHg) to afford 89 g (75% yield) of the desired product as a pale yellow oil.

References:
[1] Patent: US2005/282820, 2005, A1. Location in patent: Page/Page column 17-18
[2] Journal of the Chemical Society - Perkin Transactions 1, 1999, # 7, p. 803 - 810
[3] Journal of the American Chemical Society, 1947, vol. 69, p. 795,796

Category	Value
Hazard Symbol	Xn, Xi, C, F
Hazard Codes (R Phrases)	22-36/37/38-34-11
Safety Codes (S Phrases)	23-26-36/37/39-45-16
Hazard Class	IRRITANT
HS Code (Customs)	2933998090

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6-Methylquinoxaline

CAS：6344-72-5 | 6-Methylquinoxaline | Whchem

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