2-(6-broMopyridin-2-yl)propan-2-ol

Name: 2-(6-broMopyridin-2-yl)propan-2-ol
Brand: Zhengzhou Whchem

CAS：638218-78-7 | 2-(6-broMopyridin-2-yl)propan-2-ol | Whchem

CAS: 638218-78-7

Other Names

2-(6-broMopyridin-2-yl)propan-2-ol;2-(6-Bromo-2-pyridyl)-2-propanol;2-Pyridinemethanol, 6-bromo-α,α-dimethyl-;2-(6-broMopyridin-2-yl)propan-2-ol ISO 9001：2015 REACH;2-(6-bromopyridine) -2-propanol

Structure - 2-(6-broMopyridin-2-yl)propan-2-ol

Molecular Formula

Purity

>97%

Molecular Weight

216.08 g/mol

EINECS

Structure Available Verified Product

English Name	2-(6-broMopyridin-2-yl)propan-2-ol
English Synonyms	2-(6-broMopyridin-2-yl)propan-2-ol;2-(6-Bromo-2-pyridyl)-2-propanol;2-Pyridinemethanol, 6-bromo-α,α-dimethyl-;2-(6-broMopyridin-2-yl)propan-2-ol ISO 9001：2015 REACH;2-(6-bromopyridine) -2-propanol
CAS Number	638218-78-7
Molecular Formula	C8H10BrNO
Molecular Weight	216.08 g/mol
EINECS Number
Related Categories
Mol File	Download MOL File
Structure Image

Property	Value
Boiling point	273.2±25.0 °C (Predicted)
Density	1.474±0.06 g/cm³ (Predicted)
Storage condition	under inert gas (nitrogen or Argon) at 2-8°C
Acidity Coefficient (pKa)	13.23±0.29 (Predicted)
Appearance	Colorless to off-white solid-liquid mixture
InChI	InChI=1S/C8H10BrNO/c1-8(2,11)6-4-3-5-7(9)10-6/h3-5,11H,1-2H3
InChIKey	OXSDDDKLMCHNHF-UHFFFAOYSA-N
SMILES	CC(C1=NC(Br)=CC=C1)(O)C

2-(6-broMopyridin-2-yl)propan-2-ol (CAS 638218-78-7) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 2-(6-broMopyridin-2-yl)propan-2-ol with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Synthetic Route Diagram 2-(6-Bromopyridin-2-yl)propan-2-ol	Uses & Synthesis Methods Application: 2-(6-Bromopyridin-2-yl)propan-2-ol can be used as an organic synthesis intermediate and a pharmaceutical intermediate. It is mainly used in laboratory research and development, as well as in chemical and pharmaceutical production processes. Production Method: Starting Materials: 626-05-1 (2,6-Dibromopyridine) 67-64-1 (Acetone) 638218-78-7 (2-(6-Bromopyridin-2-yl)propan-2-ol) General Procedure: In a dried 250 mL round-bottom flask equipped with a stir bar, septum, and temperature probe, a solution of 1.6 M n-butyllithium in hexane (31.2 mL, 50 mmol) was added. The reaction system was cooled to -76°C in a dry ice-acetone bath. THF (30 mL) was then added to the flask, followed by slow dropwise addition of a solution of 2,6-dibromopyridine (11.5 g, 50 mmol) in THF (60 mL) via syringe, maintaining the reaction temperature below -60°C. The deep yellow-brown solution was stirred in the dry ice bath for an additional 30 minutes, then acetone (6 mL, 80 mmol) was added. The reaction mixture was stirred in the dry ice bath for 15 minutes, then allowed to warm slowly to room temperature. After 1 hour of reaction, the mixture was carefully quenched with 5% aqueous ammonium chloride solution (50 mL). The reaction mixture was extracted with dichloromethane, and the combined organic phases were evaporated to afford 2-(6-bromopyridin-2-yl)propan-2-ol (10.6 g, 98% yield) as an orange oil. MS (m/z): 216 and 218 (M+H)⁺. References: [1] Patent: WO2009/131814, 2009, A2. Location in patent: Page/Page column 40 [2] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0461; 0462 [3] Patent: WO2014/60371, 2014, A1. Location in patent: Page/Page column 76 [4] Chemical Communications, 2016, vol. 52, # 74, p. 11056 - 11059 [5] Patent: WO2004/814, 2003, A1. Location in patent: Page 50

Category

Description (English Translation)

Uses & Synthesis Methods

Synthetic Route Diagram

2-(6-Bromopyridin-2-yl)propan-2-ol

Uses & Synthesis Methods

Application: 2-(6-Bromopyridin-2-yl)propan-2-ol can be used as an organic synthesis intermediate and a pharmaceutical intermediate. It is mainly used in laboratory research and development, as well as in chemical and pharmaceutical production processes.

Production Method:

Starting Materials:

626-05-1 (2,6-Dibromopyridine)

67-64-1 (Acetone)

638218-78-7 (2-(6-Bromopyridin-2-yl)propan-2-ol)

General Procedure: In a dried 250 mL round-bottom flask equipped with a stir bar, septum, and temperature probe, a solution of 1.6 M n-butyllithium in hexane (31.2 mL, 50 mmol) was added. The reaction system was cooled to -76°C in a dry ice-acetone bath. THF (30 mL) was then added to the flask, followed by slow dropwise addition of a solution of 2,6-dibromopyridine (11.5 g, 50 mmol) in THF (60 mL) via syringe, maintaining the reaction temperature below -60°C. The deep yellow-brown solution was stirred in the dry ice bath for an additional 30 minutes, then acetone (6 mL, 80 mmol) was added. The reaction mixture was stirred in the dry ice bath for 15 minutes, then allowed to warm slowly to room temperature. After 1 hour of reaction, the mixture was carefully quenched with 5% aqueous ammonium chloride solution (50 mL). The reaction mixture was extracted with dichloromethane, and the combined organic phases were evaporated to afford 2-(6-bromopyridin-2-yl)propan-2-ol (10.6 g, 98% yield) as an orange oil. MS (m/z): 216 and 218 (M+H)⁺.

References:

[1] Patent: WO2009/131814, 2009, A2. Location in patent: Page/Page column 40

[2] Patent: US2013/178478, 2013, A1. Location in patent: Paragraph 0461; 0462

[3] Patent: WO2014/60371, 2014, A1. Location in patent: Page/Page column 76

[4] Chemical Communications, 2016, vol. 52, # 74, p. 11056 - 11059

[5] Patent: WO2004/814, 2003, A1. Location in patent: Page 50

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2-(6-broMopyridin-2-yl)propan-2-ol

CAS：638218-78-7 | 2-(6-broMopyridin-2-yl)propan-2-ol | Whchem

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