2-THIOPHEN-2-YL-BENZALDEHYDE

Name: 2-THIOPHEN-2-YL-BENZALDEHYDE
Brand: Zhengzhou Whchem

CAS：99902-07-5 | 2-THIOPHEN-2-YL-BENZALDEHYDE | Whchem

CAS: 99902-07-5

Other Names

2-THIOPHEN-2-YL-BENZALDEHYDE;2-THIEN-2-YLBENZALDEHYDE;2-(2-THIENYL)BENZALDEHYDE;AKOS BAR-0192;2-(Thien-2-yl)benzaldehyde 97%;2-(Thien-2-yl)benzaldehyde97%;Benzaldehyde, 2-(2-thienyl)-;2-Thienylbenzaldehyde

Structure - 2-THIOPHEN-2-YL-BENZALDEHYDE

Molecular Formula

Purity

>97%

Molecular Weight

188.25 g/mol

EINECS

Structure Available Verified Product

English Name	2-THIOPHEN-2-YL-BENZALDEHYDE
English Synonyms	2-THIOPHEN-2-YL-BENZALDEHYDE;2-THIEN-2-YLBENZALDEHYDE;2-(2-THIENYL)BENZALDEHYDE;AKOS BAR-0192;2-(Thien-2-yl)benzaldehyde 97%;2-(Thien-2-yl)benzaldehyde97%;Benzaldehyde, 2-(2-thienyl)-;2-Thienylbenzaldehyde
CAS Number	99902-07-5
Molecular Formula	C11H8OS
Molecular Weight	188.25 g/mol
EINECS Number
Related Categories	Aldehydes;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
Mol File	Download MOL File
Structure Image

Property	Value
Storage condition	under inert gas (nitrogen or Argon) at 2–8 °C
Appearance	Colorless to pale yellow liquid

2-THIOPHEN-2-YL-BENZALDEHYDE (CAS 99902-07-5) is a high-purity fine chemical intermediate widely used in organic synthesis, pharmaceutical R&D, agrochemical manufacturing and specialty chemical applications.

As a professional supplier, Zhengzhou Whchem provides 2-THIOPHEN-2-YL-BENZALDEHYDE with >97% purity, COA, structure confirmation and flexible packaging, available from research quantities to commercial scale with global shipping.

Category	Description (English Translation)
Uses & Synthesis Methods Production Method: Starting Materials: 1003-09-4 (2-Bromothiophene) 40138-16-7 (2-Formylphenylboronic acid) 99902-07-5 (2-(Thiophen-2-yl)benzaldehyde) In a 100 mL three-necked flask, 3.0 g (20 mmol) of 2-bromothiophene (Compound a-1), 4.24 g (26 mmol) of 2-formylphenylboronic acid (Compound a-2), 10.6 g (100.0 mmol) of sodium carbonate, 30 mL of toluene, 10 mL of ethanol, and 20 mL of water were added. Under a nitrogen atmosphere, the mixture was stirred at room temperature, and then 693 mg of tetrakis(triphenylphosphine)palladium(0) was added. The reaction mixture was heated to 80°C and stirred for 5 hours. After the reaction was complete, the organic layer was extracted with toluene and dried over anhydrous sodium sulfate. Purification by silica gel column chromatography (eluent: toluene/heptane mixture) afforded 3.46 g (92% yield) of the target product, 2-(thiophen-2-yl)benzaldehyde (Intermediate a-3), as a white oil. References: [1] Patent: WO2011/132623, 2011, A1. Location in patent: Page/Page column 28-29 [2] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 6, p. 515 - 518 [3] Tetrahedron, 2008, vol. 64, # 38, p. 9033 - 9043 [4] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 6264 - 6267

Category

Description (English Translation)

Uses & Synthesis Methods

Production Method:

Starting Materials:
1003-09-4 (2-Bromothiophene)
40138-16-7 (2-Formylphenylboronic acid)
99902-07-5 (2-(Thiophen-2-yl)benzaldehyde)

In a 100 mL three-necked flask, 3.0 g (20 mmol) of 2-bromothiophene (Compound a-1), 4.24 g (26 mmol) of 2-formylphenylboronic acid (Compound a-2), 10.6 g (100.0 mmol) of sodium carbonate, 30 mL of toluene, 10 mL of ethanol, and 20 mL of water were added. Under a nitrogen atmosphere, the mixture was stirred at room temperature, and then 693 mg of tetrakis(triphenylphosphine)palladium(0) was added. The reaction mixture was heated to 80°C and stirred for 5 hours. After the reaction was complete, the organic layer was extracted with toluene and dried over anhydrous sodium sulfate. Purification by silica gel column chromatography (eluent: toluene/heptane mixture) afforded 3.46 g (92% yield) of the target product, 2-(thiophen-2-yl)benzaldehyde (Intermediate a-3), as a white oil.

References:
[1] Patent: WO2011/132623, 2011, A1. Location in patent: Page/Page column 28-29
[2] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 6, p. 515 - 518
[3] Tetrahedron, 2008, vol. 64, # 38, p. 9033 - 9043
[4] Journal of Organic Chemistry, 2002, vol. 67, # 17, p. 6264 - 6267

Category	Value
Hazard Symbol	Xi
Hazard Codes (R Phrases)	20/22-36/37/38-41
Safety Codes (S Phrases)	23-26-36-39
Hazard Note	Irritant
HS Code (Customs)	2934999090

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2-THIOPHEN-2-YL-BENZALDEHYDE

CAS：99902-07-5 | 2-THIOPHEN-2-YL-BENZALDEHYDE | Whchem

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